Reference data

TitleDevelopment of a photoswitchable antagonist of NMDA receptors
AuthorFelix W.W. Hartrampf a, David M. Barber a, Kevin Gottschling b, Philipp Leippe a, Michael Hollmann b, Dirk Traunera, c,
Affiliation(s)a Department of Chemistry and Pharmacology, Ludwig-Maximilians-Universität, München, and Center for Integrated Protein Science, Munich, 81377, Germany b Ruhr University Bochum, Department of Biochemistry I – Receptor Biochemistry, Bochum, 44780, Germany c Department of Chemistry, New York University, New York, NY, 10003, USA
PublishedTetrahedron 28 June 2017 https://doi.org/10.1016/j.tet.2017.06.056
Keywordglutamate receptor; Antagonist; Azobenzene; Photopharmacology; Photoswitch
AbstractN-methyl-D-aspartate receptors (NMDARs) are vital for neurological processes such as learning, memory, and synaptic plasticity. As such, small molecules that modulate their function are of interest in the study of numerous neurological diseases. We have synthesized a small library of photoswitches that modulate NMDAR function. The most efficient photoswitch to date is based on a known ligand of the glycine binding site and shows significant subtype selectivity.


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