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TitleVolume Conduction Coupling of Whisker-Evoked Cortical LFP in the Mouse Olfactory Bulb
AuthorAna Parabucki, Ilan Lampl
Affiliation(s)Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel
PublishedCell Reports Volume 21, Issue 4, p919–925, 24 October 2017 http://dx.doi.org/10.1016/j.celrep.2017.09.094
Keyword 
SnippetTo activate ChR2, an LED light source of 460 nm (Prizmatix Opt-LED-460, Givat-Shmuel, Israel) was coupled to a bare optical fiber (200-mm diameter, 0.22 NA; ThorLabs M25L05, Newton, NJ, USA) and placed above the cortex
AbstractLocal field potentials (LFPs) are an important measure of brain activity and have been used to address various mechanistic and behavioral questions. We revealed a prominent whisker-evoked LFP signal in the olfactory bulb and investigated its physiology. This signal, dependent on barrel cortex activation and highly correlated with its local activity, represented a pure volume conduction signal that was sourced back to the activity in the ventro-lateral orbitofrontal cortex, located a few millimeters away. Thus, we suggest that special care should be taken when acquiring and interpreting LFP data.

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