| Title | Volume Conduction Coupling of Whisker-Evoked Cortical LFP in the Mouse Olfactory Bulb |
| Author | Ana Parabucki, Ilan Lampl |
| Affiliation(s) | Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel |
| Published | Cell Reports Volume 21, Issue 4, p919–925, 24 October 2017 http://dx.doi.org/10.1016/j.celrep.2017.09.094 |
| Keyword | |
| Snippet | To activate ChR2, an LED light source of 460
nm (Prizmatix Opt-LED-460, Givat-Shmuel, Israel) was coupled to a bare optical fiber (200-mm
diameter, 0.22 NA; ThorLabs M25L05, Newton, NJ, USA) and placed above the cortex |
| Abstract | Local field potentials (LFPs) are an important measure of brain activity and have been used to address various mechanistic and behavioral questions. We revealed a prominent whisker-evoked LFP signal in the olfactory bulb and investigated its physiology. This signal, dependent on barrel cortex activation and highly correlated with its local activity, represented a pure volume conduction signal that was sourced back to the activity in the ventro-lateral orbitofrontal cortex, located a few millimeters away. Thus, we suggest that special care should be taken when acquiring and interpreting LFP data. |
