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TitleEnhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus
AuthorJi Liu 1, 2, Kristie Conde 1, 2, Peng Zhang 3, Varoth Lilascharoen 4, Zihui Xu 1, 2, Byung Kook Lim 4, Randy J. Seeley 5, J. Julius Zhu 3, Michael M. Scott 3, , , Zhiping P. Pang 1, 2, 6,
Affiliation(s)1 Child Health Institute of New Jersey, Rutgers University Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA 2 Department of Neuroscience and Cell Biology, Rutgers University Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA 3 Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA 4 Neurobiology Section, Division of Biological Science, University of California San Diego, CA 92093, USA 5 Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
PublishedNeuron Volume 96, Issue 4, 15 November 2017, Pages 897–909.e5 https://doi.org/10.1016/j.neuron.2017.09.042
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AbstractGlucagon-like Peptide 1 (GLP-1)-expressing neurons in the hindbrain send robust projections to the paraventricular nucleus of the hypothalamus (PVN), which is involved in the regulation of food intake. Here, we describe that stimulation of GLP-1 afferent fibers within the PVN is sufficient to suppress food intake independent of glutamate release. We also show that GLP-1 receptor (GLP-1R) activation augments excitatory synaptic strength in PVN corticotropin-releasing hormone (CRH) neurons, with GLP-1R activation promoting a protein kinase A (PKA)-dependent signaling cascade leading to phosphorylation of serine S845 on GluA1 AMPA receptors and their trafficking to the plasma membrane. Finally, we show that postnatal depletion of GLP-1R in the PVN increases food intake and causes obesity. This study provides a comprehensive multi-level (circuit, synaptic, and molecular) explanation of how food intake behavior and body weight are regulated by endogenous central GLP-1.

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