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TitleProgressive Cationic Functionalization of Chlorin Derivatives for Antimicrobial Photodynamic Inactivation and Related Vancomycin Conjugate
AuthorLiyi Huang,‡,§ Min Wang,† Ying-Ying Huang,‡,§ Ahmed El-Hussein,‡,§ Lawrence Wolf, † Long Y. Chiang,*,† and Michael R. Hamblin*,‡,§,¥
Affiliation(s)‡ Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, United States § Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02115, United States † Department of Chemistry, University of Massachusetts Lowell, Lowell, Massachusetts 01854, United States ¥ Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, United States
PublishedPhotochemical @ Photobiological Sciences Iss. 5 2018 DOI: 10.1039/C7PP00389G
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AbstractIt is known that multiple cationic charges are required to produce broad-spectrum antimicrobial photosensitizers (PS) for photodynamic inactivation (aPDI) or photodynamic therapy of bacteria and fungi. In the present study we describe the synthesis and aPDI testing of a set of derivatives prepared from the parent pheophytin molecule with different numbers of attached side arms (1–3) each consisting of five quaternized cationic groups (pentacationic), producing the corresponding ....

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