| Title | Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice |
| Author | Marita G. Hansen, Litsa N. Ledri, Deniz Kirik, Merab Kokaia and Marco Ledri |
| Affiliation(s) | 1 Epilepsy Center, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden
2 Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden |
| Published | Front. Cell. Neurosci., 09 January 2018 | https://doi.org/10.3389/fncel.2017.00433 |
| Keyword | |
| Snippet | Light was generated by a 460 nm wavelength LED light source (Prizmatix, Modiin Ilite, Israel) and stimulation of pre-synaptic PV-ChR2-expressing cells was achieved via 1 ms width light pulses … |
| Abstract | Parvalbumin- (PV-) containing basket cells constitute perisomatic GABAergic inhibitory interneurons innervating principal cells at perisomatic area, a strategic location that allows them to efficiently control the output and synchronize oscillatory activity at gamma frequency (30–90 Hz) oscillations. This oscillatory activity can convert into higher frequency epileptiform activity, and therefore could play an important role in the generation of seizures. |
