| Title | CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature |
| Author | Antoine Louveau, Jasmin Herz, Maria Nordheim Alme, Andrea Francesca Salvador, Michael Q. Dong, Kenneth E. Viar, S. Grace Herod, James Knopp, Joshua C. Setliff, Alexander L. Lupi, Sandro Da Mesquita, Elizabeth L. Frost, Alban Gaultier, Tajie H. Harris, Rui Cao, Song Hu, John R. Lukens, Igor Smirnov, Christopher C. Overall, Guillermo Oliver & Jonathan Kipnis |
| Affiliation(s) | Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA, USA
Department of Neuroscience, University of Virginia, Charlottesville, VA, USA |
| Published | Nature Neuroscience volume 21, 2018 https://doi.org/10.1038/s41593-018-0227-9 |
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| Abstract | Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link between the CNS and peripheral immune system, perhaps affecting autoimmunity. .. |
