| Title | Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy |
| Author | Kazuo Takayama*†‡§ and Hiroyuki Mizuguchi*†§∥ |
| Affiliation(s) | † Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan
‡ PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan
§ Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan
∥ Global Center for Medical Engineering and Informatics, Osaka University, Osaka 565-0871, Japan |
| Published | ACS Chem. Biol., 2018, 13 (2), pp 449–454 DOI: 10.1021/acschembio.7b01058 |
| Keyword | |
| Snippet | |
| Abstract | Gene therapy is expected to be utilized for the treatment of various diseases. However, the spatiotemporal resolution of current gene therapy technology is not high enough. In this study, we generated a new technology for spatiotemporally controllable gene therapy. We introduced optogenetic and CRISPR/Cas9 techniques into a recombinant adenovirus (Ad) vector, which is widely used in clinical trials and exhibits high gene transfer efficiency,.... |
