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TitleLight-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles
AuthorPatrick Urban† , Stefanie D. Pritzl†, David B. Konrad‡, James A. Frank‡, Carla Pernpeintner†∥, Christian R. Roeske†, Dirk Trauner*‡§∥ , and Theobald Lohmüller*†∥
Affiliation(s)† Photonics and Optoelectronics Group, Department of Physics and CeNS, Ludwig-Maximilians-Universität München, Amalienstraße 54, 80799 Munich, Germany ‡ Department of Chemistry and Center for Integrated Protein Science, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 Munich, Germany § Department of Chemistry, New York University, Silver Center, 100 Washington Square East, Room 712, New York 10003, United States ∥ Nanosystems Initiative Munich, Schellingstraße 4, 80799 Munich, Germany
PublishedLangmuir, 2018, 34 (44), pp 13368–13374 DOI: 10.1021/acs.langmuir.8b03241
AbstractControlling lateral interactions between lipid molecules in a bilayer membrane to guide membrane organization and domain formation is a key factor for studying and emulating membrane functionality in synthetic biological systems. Here, we demonstrate an approach to reversibly control lipid organization, domain formation, and membrane stiffness of phospholipid bilayer membranes using the photoswitchable phospholipid azo-PC. azo-PC contains an azobenzene group in the sn2 acyl chain that undergoes reversible photoisomerization on illumination with UV-A and visible light.


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