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TitleFast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning
AuthorScott F.Owen1Joshua D.Berke234Anatol C.Kreitzer12
Affiliation(s)1 Gladstone Institutes, San Francisco, CA 94158, USA 2 Department of Neurology, UCSF, San Francisco, CA 94158, USA 3 Kavli Institute for Fundamental Neuroscience, UCSF, San Francisco, CA 94158, USA 4 UCSF Weill Institute for Neurosciences, UCSF, San Francisco, CA 94158, USA 5 Department of Physiology, UCSF, San Francisco, CA 94158, USA
PublishedCell, vol.172 iss.4 Feb. 2018 https://doi.org/10.1016/j.cell.2018.01.005
AbstractFast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrophysiology, imaging, and behavior to describe a unified mechanism by which striatal FSIs control burst firing, calcium influx, and synaptic plasticity in neighboring medium spiny projection neurons (MSNs)....


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